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KMID : 0941820080180010028
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Korean Journal of Clinical Pharmacy
2008 Volume.18 No. 1 p.28 ~ p.37
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Pharmacoeconomic Evaluation of Antimuscarinic Agents for the Treatment of Overactive Bladder - With Solifenacin and Tolterodine IR -
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Park Sun-Young
Lee Eui-Kyung
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Abstract
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Objectives: Overactive bladder(OAB), defined as ‘urgency, with or without urge incontinence, usually with frequency and nocturia’, is a major burden for patients and impairs quality of life. The aim of this study is to evaluate the cost-effectiveness of antimuscarinic agents for the treatment of overactive bladder including quality of life in societal perspective.
Methods: A decision-analysis model was developed to compare the cost-effectiveness of solifenacin and tolterodine IR over 12 weeks. We used data from the published literature to develop the framework for the model. Resource utilization and costs were calculated with public institutional data and supplemented this information with clinical expert opinion, where necessary.
Results: The expected costs per patient for solifenacin were 48,762 KRW less expensive than tolterodine IR over 12 weeks. Also, all outcomes including quality of life for solifenacin were more effective than tolterodine IR over 12 weeks. In conclusion, solifenacin dominates tolterodine IR and appears to be cost-effective options for the management of overactive bladder.
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KEYWORD
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Solifenacin, Tolterodine IR, overactive bladder, quality of life, cost-effectiveness analysis
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